Statins

A recent study concluded that Ursodeoxycholic acid (UDCA) can delay the tendency of statins to induce glucose intolerance and diabetes.

About Statins:

• Statins are cholesterol-lowering drugs commonly prescribed to reduce the risk of cardiovascular disease.
• They are listed as essential medicines by the World Health Organization and are among the most sold drugs worldwide.
• Common statins include Atorvastatin, Fluvastatin, Lovastatin, Rosuvastatin, etc.
• Statins are recommended for individuals with high risk of heart attack or stroke, high LDL cholesterol, and diabetes.
• Statins block the enzyme HMG-CoA reductase, which is involved in the production of LDL cholesterol in the liver.
• They help draw cholesterol out of plaque in the arteries, reducing the risk of heart attack and stroke.
• Statins may also decrease triglyceride levels and increase HDL or good cholesterol.
• Their common side effects of statins include muscle damage, constipation, diarrhea, nausea, headache, dizziness, and fatigue.
• Studies suggest a potential risk of frank/pre-diabetes with statin use, but benefits often outweigh risks.

About Ursodeoxycholic Acid (UDCA):

• UDCA, also known as ursodiol, is a secondary bile acid produced in the liver and by intestinal or gut bacteria.
• It is used to treat or prevent various liver or bile duct diseases.

About Cholesterol:

• Cholesterol is a vital substance in the body, crucial for cell function and hormone production.
• Imbalances in cholesterol levels can lead to health issues, including cardiovascular diseases.

Types of Cholesterol:

• Low-Density Lipoprotein (LDL) is often referred to as “bad” cholesterol because it can build up on the walls of arteries.
• It forms plaque that can narrow and block blood vessels, leading to heart disease and stroke.
• High-density Lipoprotein (HDL) is known as “good” cholesterol as it helps remove LDL cholesterol from the bloodstream.
• It transports it to the liver where it can be broken down and excreted from the body.

Impacts and management of High Cholesterol:

• High cholesterol levels can increase the risk of cardiovascular diseases such as atherosclerosis, heart attacks, and strokes.
• Cholesterol buildup can also lead to hypertension, peripheral artery disease, and the development of xanthomas (fatty deposits under the skin).
• Managing cholesterol levels involves adopting a healthy diet low in saturated and trans fats.
• Regular exercise can help boost HDL cholesterol levels.
• Medications such as statins may be prescribed to lower LDL cholesterol levels.
• Lifestyle modifications such as quitting smoking, maintaining a healthy weight, and managing stress are also important for cholesterol management.

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